The Bubonic Plague | The Past, Present And Future

Imagine if half the people in your neighborhood, your city, or even your whole country were wiped out. It might sound like something out of an apocalyptic horror film, but it actually happened in the 14th century during a disease outbreak known as the Black Death.

Spreading from China through Asia, the Middle East, Africa and Europe, the devastating epidemic destroyed as much as 1/5 of the world's population, killing nearly 50% of Europeans in just four years.

A suspected case of bubonic plague has been reported to Chinese authorities. It is not known how the patient became infected, but the country is on alert for more cases. Plague is one of the deadliest diseases in human history - but it can now be easily treated with antibiotics. (BBC)

One of the most fascinating and puzzling things abut the Black Death is that the illness itself was not a new phenomenon but one that has affected humans for centuries.

DNA analysis of bone and tooth samples from this period, as well as an earlier epidemic known as the Plague of Justinian in 541 CE, has revealed that both were caused by Yersinia pestis, the same bacterium that causes bubonic plague today.

What this means is that the same disease caused by the same pathogen can behave and spread very differently throughout history.

Even before the use of antibiotics, the deadliest oubreaks in modern times, such as the ones that occurred in early 20th century India, killed no more than 3% of the population. Modern instances of plague also tend to remain localized,or travel slowly, as they are spread by rodent fleas.

But the medieval Black Death, which spread like wildfire, was most likely communicated directly from one person to another. And because genetic comparisons of ancient to modern strains of Yersinia pestis have not revealed any significantly functional genetic differences, the key to why the earlier outbreak was so much deadlier must lie not in the parasite but the host.

For about 300 years during the High Middle Ages, a warmer climate and agricultural improvements had led to explosive population growth throughout Europe. But with so many new mouths to feed, the end of this warm period spelled disaster.

A person usually becomes ill with bubonic plague between two and six days after being infected. Along with the tender, enlarged lymph nodes, that can be as large as a chicken egg, other symptoms include fever, chills, headache, muscle aches and tiredness. Plague can also affect the lungs, causing a cough, chest pain and difficulty breathing. The bacteria can also enter the bloodstream and cause a condition called septicaemia or sepsis, which can lead to tissue damage, organ failure and death. (BBC)

High fertility rates combined with reduced harvest, meant the land could no longer support its population, while the abundant supply of labor kept wages low. As a result, most Europeans in the early 14th century experienced a steady decline in living standards, marked by famine, poverty and poor health, leaving them vulnerable to infection.

And indeed, the skeletal remains of Black Death victims found in London show telltale signs of malnutrition and prior illness.

The destruction caused by the Black Death changed humanity in two important ways. On a societal level, the rapid loss of population led to important changes in Europe's economic conditions. With more food to go around, as well as more land and better pay for the surviving farmers and workers, people began to eat better and live longer as studies of London cemeteries have shown.

Higher living standards also brought an increase in social mobility, weakening feudalism, and eventually leading to political reforms.

People can catch it from: Bites of infected fleas; Touching infected animals such as rats and mice; Inhaling infected respiratory droplets spread by infected people or animals. - Domestic cats and dogs can become infected from flea bites or from eating infected rodents. The infection could also enter the body through a cut in the skin if the person came in close contact with an infected animal's blood. - The current alert in China forbids the hunting and eating of animals that could carry plague. (BBC)

But the plague also had an important biological impact. The sudden death of so many of the most frail and vulnerable people left behind a population with a significantly different gene pool, including genes that may have helped survivors resist the disease. And because such mutations often confer immunities to multiple pathogens that work in similar ways, research to discover the genetic consequences of the Black Death has the potential to be hugely beneficial.

Today, the threat of an epidemic on the scale of the Black Death has been largely eliminated thanks to antibiotics.

But the bubonic plague continues to kill a few thousand people worldwide every year, and the recent emergence of a drug-resistant strain threatens the return of darker times.

Learning more about the causes and effects of the Black Death is important, not just for understanding how our world has been shaped by the past. It may also help save us from a similar nightmare in the future.

Source: TED-Ed / Sharon N. DeWitte.

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